Talk:Krabbe disease

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
WikiProject Medicine / Medical genetics / Neurology (Rated Start-class, Low-importance)
WikiProject iconThis article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.
Start-Class article Start  This article has been rated as Start-Class on the project's quality scale.
 Low  This article has been rated as Low-importance on the project's importance scale.
Taskforce icon
This article is supported by the Medical genetics task force.
Taskforce icon
This article is supported by the Neurology task force (marked as Mid-importance).
 

WikiProject class rating[edit]

This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:28, 10 November 2007 (UTC)

Questions about Incidence section[edit]

I'm a long-time fan of wikipedia, but new to editing pages.
I'd like to propose the "Incidence" section be modified. The 1/100,000 incidence estimate can be attributed to the book chapter by Wenger et al. ("Galactosylceramide lipidosis: globoid cell leukodystrophy (Krabbe disease)", in The metabolic and molecular bases of inherited disease, 8th Ed., 2001, Scriver, Beaudet, Sly, Valle, Eds.), but since the units of this estimate is not cases per person-years at risk, it can not be an incidence measure. The authors provide no indication as to how the 1/100,000 statistic was calculated, and furthermore, the lead author (DA Wenger) no longer describes this 1/100,000 estimate as "incidence" in his latest chapter on Krabbe disease ("Krabbe Disease (Globoid Cell Leukodystrophy)", in Leukodystrophies, 2011, Raymond, Eichler, Fatemi, Naidu, Eds.). I propose that this statistic be removed, and replaced with estimates of birth prevalence from some (or all) of 7 epidemiology papers whose bibliographic information I will provide below. The section header will need to be changed from "Incidence" to "Epidemiology." I propose a sentence along the lines of:

"The birth prevalence of Krabbe disease is estimated to be in the range between
0.29 to 1.35 per 100,000 births (refs)"

Poupetova, Ledvinova, Berna, et al. 2010. The birth prevalence of lysosomal storage disorders in the Czech Republic: comparison with data in different populations J Inherit Metab Dis 33(4): 387-396
Ozkara & Topcu 2004. Sphingolipidoses in Turkey Brain and Development 26(6): 363-366
Poorthuis, Wevers, Kleijer, et al. 1999. The frequency of lysosomal storage diseases in The Netherlands Hum Genet 105: 151-156
Applegarth, Toone, & Lowry 2000. Incidence of Inborn Errors of Metabolism in British Columbia, 1969-1996 Pediatrics 105(1)
Meikle, Hopwood, Clague et al. 1999. Prevalence of Lysosomal Storage Disorders JAMA 281(3): 249-254
Pinto, Caseiro, Lemos, et al. 2004. Prevalence of lysosomal storage diseases in Portugal Eur J Hum Genet 12: 87-92
Heim, Claussen, Hoffmann, et al. 1997. Leukodystrophy Incidence in Germany Am J Med Genet 71: 475-478

--Afossbio (talk) 16:51, 21 June 2011 (UTC)

External links modified[edit]

Hello fellow Wikipedians,

I have just modified one external link on Krabbe disease. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

As of February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{sourcecheck}} (last update: 15 July 2018).

  • If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
  • If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 17:26, 12 December 2017 (UTC)

External links modified[edit]

Hello fellow Wikipedians,

I have just modified one external link on Krabbe disease. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

As of February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{sourcecheck}} (last update: 15 July 2018).

  • If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
  • If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 00:19, 27 December 2017 (UTC)