Type I cytokine receptor
|Type I cytokine receptor, cytokine-binding domain|
|SCOPe||1n26 / SUPFAM|
Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
The common cytokine-binding domain is related to the Fibronectin type III domain.
Signal transduction chains
The signal transducing chains are often shared between different receptors within this receptor family.
- The IL-2 receptor common gamma chain (also known as CD132) is shared between:
- The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
- The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
- Interleukin-1 receptor
- Interleukin-2 receptor
- Interleukin-3 receptor
- Interleukin-4 receptor
- Interleukin-5 receptor
- Interleukin-6 receptor
- Interleukin-7 receptor
- Interleukin-9 receptor
- Interleukin-11 receptor
- Interleukin-12 receptor
- Interleukin-13 receptor
- Interleukin-15 receptor
- Interleukin-18 receptor
- Interleukin-21 receptor
- Interleukin-23 receptor
- Interleukin-27 receptor
Colony stimulating factor receptors
Hormone receptor/neuropeptide receptor
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